UGT1A10 (3-g) | 1A10-F93G (3-g) | UGT2B7 (16-g or 17-g) | |
---|---|---|---|
Estriol | (16-g) | ||
Vmax (pmol/min/mg) | 1200 ± 28.1 | 7535 ± 618 | 1509 ± 27.7 |
Km (µM) | 68.4 ± 4.7 | 230 ± 29.7 | 10.3 ± 0.8 |
16-epiestriol | (16-g) | ||
Vmax (pmol/min/mg) | 7700 ± 740 | 2249 ± 201 | 3866 ± 788 |
Km (µM) | 59.8 ± 8.0 | 186 ± 28.0 | 38.4 ± 11.4 |
Ki (µM)a | 98.1 ± 16.6 | 162 ± 86.4 | |
17-epiestriol | (17-g) | ||
Vmax (pmol/min/mg) | 958 ± 75.0 | 5712 ± 216 | 820 ± 18.3 |
Km (µM) | 337 ± 42.1 | 51.1 ± 5.4 | 0.6 ± 0.1 |
UGTs, UDP-glucuronosyltransferases.
↵a Ki values are indicated when the kinetic curves fit best to the Michaelis-Menten with substrate inhibition model.