TABLE 3

Kinetic parameters of brain distribution of pemetrexed and methotrexate

	Cl_in/Cl_eff	k_eff	V_d,brain	Cl_eff
		min⁻¹	ml/g brain	μl/min·g brain
Pemetrexed	0.106^a	0.0178 ± 0.0031	0.62 ± 0.10	11.04
Methotrexate	0.05^b	0.0238 ± 0.0028	0.85 ± 0.06	20.23

Cl_eff, efflux clearance; Cl_in, clearance into brain; V_d,brain, brain distribution volume.
↵^a Dai et al., 2005.
↵^b Devineni et al., 1996.