TABLE 2

Radioactivity tissue concentrations greater than blood at 48 hours, 1 week, and 3 weeks after i.v. administration of 2.1 mg/kg [14C]peginesatide in monkeys

Tissue48-Hour Value1-Week Value3-Week Value
µg equiv/gµg equiv/gμg equiv/g
Blood11.03.87BLQ
Adrenal gland (capsule)6.686.043.84
Adrenal gland (medulla)7.063.232.06
Pituitary gland3.694.752.07
Bone marrow3.224.932.32
Lymph node2.643.904.52
Spleen, red pulp7.7729.123.4
Spleen, white pulp3.043.714.74
Kidney (medulla)7.963.170.622
Lung9.602.660.264
Nasal turbinates6.502.100.728
Urinary bladder (contents)4.094.980.233
Bile1.670.632BLQ
Large intestine (contents)1.810.365BLQ
Small intestine (contents)0.166BLQBLQ
  • BLQ, below the lower limit of quantification (i.e., 0.106 μg equiv/g of tissue).