TABLE 3

Pharmacokinetic parameters of tecadenoson in plasma after 0.1 mg/kg i.v. bolus dose and fludarabine after 60 mg/kg i.v. bolus dose with and without pretreatment with NBMPR-P

Data are presented as means ± S.D. (n = 4).

Compound	V_ss	CL	t_1/2	AUC_0-∞
	l/kg	l/h per kg	h	ng⋅h/ml
Tecadenoson	2.8 ± 0.6	6.2 ± 0.9	0.7 ± 0.1	16.4 ± 2.3
Tecadenoson + NBMPR-P	2.2 ± 0.4	2.0 ± 0.2	1.1 ± 0.2	50.5 ± 5.5
Fludarabine	1.6 ± 0.2	1.5 ± 0.2	1.7 ± 0.5	39,600 ± 4560
Fludarabine + NBMPR-P	2.6 ± 0.3	0.9 ± 0.1	2.2 ± 0.6	65,700 ± 10,300

AUC_0-∞, area under the concentration-time curve extrapolated to infinity; CL, apparent total body clearance of the drug from plasma; NBMPR-P, nitrobenzylmercaptopurine riboside 5′-monophosphate; t_1/2, elimination half-life; V_ss, apparent volume of distribution at steady state.