Plasma levels of PPI-2458 and metabolites after 3 mg/kg oral dose of PPI-2458, and plasma levels after 3 mg/kg oral dose of respective metabolite
Data are given for individual animals. Limits of quantitation: PPI-2458, 0.1 ng/ml; M1, 0.1 ng/ml; M2, 0.5 ng/ml; M3, 0.1 ng/ml; M4, 0.1 ng/ml.
| Oral Dose of PPI-2458 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| PPI-2458 ng/ml | M1 ng/ml | M2 ng/ml | M3 ng/ml | M4 ng/ml | |||||
| 4 h | 24 h | 4 h | 24 h | 4 h | 24 h | 4 h | 24 h | 4 h | 24 h |
| 0.25 | BLQ | BLQ | BLQ | 1.7 | BLQ | 0.6 | BLQ | 1.1 | 0.28 |
| 0.59 | BLQ | BLQ | BLQ | 3.8 | BLQ | 1.4 | BLQ | 1.0 | BLQ |
| 0.82 | BLQ | BLQ | BLQ | 2.5 | BLQ | 0.94 | BLQ | 1.3 | 0.13 |
| Oral Dose of Respective Metabolite | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| M1 ng/ml | M2 ng/ml | M3 ng/ml | M4 ng/ml | ||||||
| 4 h | 24 h | 4 h | 24 h | 4 h | 24 h | 4 h | 24 h | ||
| 1.6 | 0.26 | 0.33 | BLQ | 0.62 | BLQ | 0.82 | BLQ | ||
| 1.6 | 0.44 | 2.94 | BLQ | 0.90 | BLQ | 0.80 | BLQ | ||
| 2.3 | 0.10 | 0.54 | BLQ | 0.52 | BLQ | 0.92 | BLQ | ||