Dog plasma abundance of LY2090314 parent and metabolites
See Supplemental Figs. 1 and 2 and Supplemental Tables 1 and 2 for a detailed summary of the metabolite identification data.
| Peak | [M+H]+ | Proposed Metabolite | % Radiochemical Peak Areaa | |
|---|---|---|---|---|
| 0.5 Hours (Tmax) | 2 Hours | |||
| P | 513 | LY2090314 | 82.76 | 36.09 |
| M4 | 445 | Parent − C5H8 | 0.10 | 0.00 |
| M22 | 545 | Parent + 2 O | 0.72 | 0.73 |
| M23 | 531 | Parent + H2O | 0.18 | 0.00 |
| M34 | 547 | Parent + O + H2O | 0.24 | 0.35 |
| M38 | 689 | Parent + Glucuronide | 0.00 | 40.53 |
| M39 | 689 | Parent + Glucuronide | 12.66 | 18.81 |
| M40 | 579 | Parent + 3O + H2O | 0.28 | 0.00 |
| M43 | 529 | Parent + O | 0.65 | 0.00 |
| M44 | 545 | Parent + 2O | 0.22 | 0.00 |
| M46 | 705 | Parent + O + Glucuronide | 0.25 | 1.77 |
| M48 | 721 | Parent + 2O + Glucuronide | 0.19 | 0.66 |
| M49 | 703 | Parent + O − 2H + Glucuronide | 0.00 | 0.62 |
| Total identified (% total radiochemical peak area)b | 98.3 | 99.6 | ||
| Extraction recovery of plasma radioactivity (%) | NAc | 100 | ||
| Total plasma radioactivity (ng-eq/g) | 7240 | 2080 | ||
NA, not available.
↵a Amount of each metabolite in the plasma sample is calculated as a percentage of the total radioactivity detected by high-performance liquid chromatography/radiochemical analysis.
↵b Peak area percentage was not corrected for extraction recovery.
↵c An insufficient volume of the 0.5-hour plasma remained to assess extraction recovery.