TABLE 4

Pharmacokinetic parameters of peginesatide and related compounds following a single i.v. dose of 5 mg/kg [14C]peginesatide to cynomolgus monkeys

CompoundCmaxAUC0–336 hCLt1/2
μg equiv./mlµg equiv.· h/mlml/h per kgh
Total radioactivity14011,005 (100)0.4365.1
Peginesatide1189580 (87.1)0.43664.3
Mono-PEG16.4596 (5.4)1.0534.7
OtherND829 (7.5)NDND
  • AUC, area under the plasma concentration-time curve; CL, clearance; ND, not detected; PEG, polyethylene glycol.