Regiochemical distribution of epoxyeicosatrienoic acid (EET) and epoxyoctadecamonoenoic acid (EpOME) products formed during incubation of recombinant mouse CYP2Js with arachidonic acid and linoleic acid
Data for human CYP2J2 are shown for comparison.
| Protein | Regioisomer Distribution (% Total EET) | Regioisomer Distribution (% Total EpOME) | ||||
|---|---|---|---|---|---|---|
| 14,15-EET | 11,12-EET | 8,9-EET | 5,6-EET | 12,13-EpOME | 9,10-EpOME | |
| CYP2J2 | 71 | 18 | 6 | 5 | 58 | 42 |
| CYP2J5 | 53 | 20 | 14 | 12 | 52 | 48 |
| CYP2J6 | 78 | 9 | 7 | 5 | 59 | 41 |
| CYP2J8 | 43 | 34 | 13 | 10 | 29 | 71 |
| CYP2J9 | 75 | 11 | 6 | 7 | 58 | 42 |
| CYP2J11 | 73 | 14 | 7 | 7 | 61 | 39 |
| CYP2J12 | 63 | 15 | 9 | 13 | 53 | 47 |
| CYP2J13 | 72 | 14 | 6 | 7 | 55 | 45 |