TABLE 1

Plasma pharmacokinetic parameters of peginesatide in male cynomolgus monkeys after i.v. administration

Cmax was designated as the measured value at the earliest sampling time point of 0.25 hours postdose. Data represent mean ± S.D. values; n = 4.

DoseCmaxt1/2AUC0–infCLVss
mg/kgμg/mlhμg∙h/mLml/h per kgml/kg
0.12.94 ± 0.3019.0 ± 2.082.9 ± 11.81.22 ± 0.1632.0 ± 2.3
0.513.2 ± 1.0434.0 ± 5.9646.2 ± 1040.79 ± 0.1337.9 ± 4.1
5121 ± 15.699.0 ± 37.111892 ± 23720.435 ± 0.09741.4 ± 5.7
5 [14C]140 ± 10.284.0 ± 9.5611438 ± 13220.441 ± 0.4647.6 ± 3.17
  • AUC, area under the plasma concentration-time curve; CL, clearance; Vss, volume of distribution at steady state.