Pharmacokinetic parameter estimates of TAK-441 after oral and Alzet infusion administration of TAK-441
RSEs (%) are shown in parentheses.
| Parameter | Definition | Estimate |
|---|---|---|
| CL (l/h per kg) | Clearance | 0.488 (4.16) |
| Vmax (mg/h per kg) | Maximum rate of absorption | 15.9 (22.5) |
| Km (mg/kg) | Dose of TAK-441 causing one-half maximum absorption rate (Vmax) | 63.1 (28.1) |
| V (l/kg) | Distribution volume | 0.158 (13.7) |
RSE, relative standard error.