TABLE 3

Percent dose excretion of [14C]peginesatide and associated radioactivity in monkey urine and feces after single i.v. administration of 5 mg/kg

Values in parentheses represent percent radioactivity for a given matrix at the specified time interval; n = 3. Dosing solution contained approximately 10% mono-PEG.

CompoundUrineFeces
0–168 h168–336 h0–336 h0–168 h168–336 h0–336 h
Total radioactivity47.7 (100)12.0 (100)59.7 (100)4.1 (100)2.9 (100)7.0 (100)
Peginesatide35.2 (70.8)7.4 (61.7)42.6 (71.4)BLQBLQBLQ
Mono-PEG12.1 (28.3)3.8 (31.7)15.9 (26.6)BLQBLQBLQ
Other0.4 (0.9)0.8 (6.6)1.2 (2.0)4.1 (100)2.9 (100)7.0 (100)
  • BLQ, below the lower limit of quantitation; PEG, polyethylene glycol.