TABLE 3

Excretion of radioactivity after single intravenous and oral administrations of [¹⁴C]CS-1036 to rats and monkeys

Values are expressed as mean ± S.D. (n = 4), and a dash denotes not tested.

Species	Dose/Route	Collection Period	Excretion of Radioactivity
Species	Dose/Route	Collection Period	Urine	Feces	Expired Air	Bile	Cage Washing	Total
		h	% of dose
Rat	1 mg/kg, i.v.	0–48	70.49 ± 7.96	15.66 ± 8.04	0.82 ± 1.05	—	—	86.96 ± 5.92
		0–168	77.21 ± 7.62	17.82 ± 8.83	—	—	—	95.85 ± 4.60
	1 mg/kg, oral	0–48	13.34 ± 3.53	77.59 ± 2.84	2.34 ± 0.74	—	—	93.26 ± 1.53
		0–168	15.32 ± 3.09	80.28 ± 3.88	—	—	—	97.94 ± 0.26
BDC rat	1 mg/kg, i.v.	0–48	—	—	—	0.37 ± 0.08	—	0.37 ± 0.08
	1 mg/kg, oral	0–48	—	—	—	0.59 ± 0.04	—	0.59 ± 0.04
Monkey	3 mg/kg, i.v.	0–48	80.13 ± 4.76	0.46 ± 0.16	—	—	13.70 ± 4.19	94.29 ± 1.08
	.	0–336	81.13 ± 4.92	0.66 ± 0.18	—	—	14.50 ± 4.04	96.29 ± 1.24
	3 mg/kg, oral	0–48	4.54 ± 2.23	78.50 ± 8.09	—	—	0.76 ± 0.37	83.80 ± 8.88
		0–336	5.67 ± 2.33	88.13 ± 3.04	—	—	1.35 ± 0.79	95.15 ± 1.48