Mice | Parameters | 5-MeO-DMT 2 mg/kg | 5-MeO-DMT 10 mg/kg | |||||
---|---|---|---|---|---|---|---|---|
Harmaline 0 mg/kg | Harmaline 2 mg/kg | Harmaline 5 mg/kg | Harmaline 15 mg/kg | Harmaline 0 mg/kg | Harmaline 5 mg/kg | Harmaline 15 mg/kg | ||
Wild-type | Cmax (µM) | 1.36 ± 0.16 | 1.88 ± 0.29* | 1.97 ± 0.15* | 1.93 ± 0.14* | 6.66 ± 1.13 | 13.3 ± 1.0* | 11.7 ± 1.5* |
AUC (µM⋅min)a | 25.1 ± 1.3 | 97.6 ± 12.2* | 109.5 ± 14.3* | 134.0 ± 5.0* | 227 ± 41 | 759 ± 91* | 275 ± 27* | |
Tg-CYP2D6 | Cmax (µM) | 1.19 ± 0.33 | 1.90 ± 0.29* | 1.68 ± 0.39 | 2.26 ± 0.14*# | 8.42 ± 1.03 | 10.4 ± 0.8*# | 12.0 ± 1.8* |
AUC (µM⋅min)a | 21.1 ± 2.3# | 71.1 ± 13.3*# | 76.3 ± 12.6*# | 120.6 ± 5.1*# | 249 ± 46 | 571 ± 11*# | 264 ± 41* |
↵a AUC15→105min for the treatments of 5 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT, AUC15→45min for the treatments of15 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT, and AUC15 min→∞ for all other treatments.
↵* P < 0.05 compared with corresponding values for the same genotype mice treated with the same dose of 5-MeO-DMT alone; #P < 0.05 compared with wild-type mice under the same treatment.