Mice | Parameters | 5-MeO-DMT 2 mg/kg | 5-MeO-DMT 10 mg/kg | |||
---|---|---|---|---|---|---|
Harmaline 2 mg/kg | Harmaline 5 mg/kg | Harmaline 15 mg/kg | Harmaline 5 mg/kg | Harmaline 15 mg/kg | ||
Wild-type | Cmax (µM) | 0.450 ± 0.113 | 2.61 ± 0.48* | 11.0 ± 1.5*† | 3.18 ± 0.22 | 10.9 ± 0.6† |
AUC (µM⋅min)a | 27.9 ± 7.1 | 198 ± 10* | 935 ± 166*† | 197 ± 16 | 269 ± 7† | |
Tg-CYP2D6 | Cmax (µM) | 0.406 ± 0.096 | 1.91 ± 0.14*# | 10.1 ± 0.8*† | 2.46 ± 0.51 | 10.0 ± 1.2† |
AUC (µΜ⋅min)a | 17.1 ± 3.6# | 109 ± 13*# | 416 ± 66*#† | 111 ± 7# | 234 ± 22#† |
↵a AUC15 min→∞ for the treatments of harmaline plus 2 mg/kg 5-MeO-DMT, AUC15→105min for the treatments of 5 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT, and AUC15→45min for the treatments of15 mg/kg harmaline plus 10 mg/kg 5-MeO-DMT.
↵# P < 0.05 compared with wild-type mice under the same treatment; *P < 0.05 compared with the same genotype mice treated with the same dose of 5-MeO-DMT plus 2 mg/kg harmaline; †P < 0.05 compared with the same genotype mice treated with the same dose of 5-MeO-DMT plus 5 mg/kg harmaline.