TABLE 3

Relationship of 4′-N-methyl piperazine cyanide adduct (CN) formation in rat liver microsomes to the extent of 4′-N-dealkyation in piperazine compounds

Compound	Parent		Piperazine 4′-N-Dealkylated Products^{^a}		4′-N-Methyl Piperazine CN Aadducts
Compound	m/z	Peak Area^{^b}	m/z	Peak Area^{^b}	m/z	Peak Area^{^b}
III	449	674	421	96	460	36
IV	435	722	421	247	460	273
VII	455	522	441	58	480	54
X	467	81	453	0.8	492	0.3
XI	481	99	453	1.4	492	0.3
XII	495	124	453	0.8	492	0.1
XIII	495	61	453	0.8	492	0.5
XIV	509	89	453	1.6	492	0.5

↵^a The dealkylation products were from rat liver microsome incubations without potassium CN.
↵^b Peak area was expressed as ion count per second (cps) × 10⁶.