TABLE 1

CLh,p, Fa, F, and Fg values for haloperidol, mebendazole, and ziprasidone from i.v. and oral data

These data were obtained from a report by Varma et al. (2010).

CompoundCLh,pFaFFg,observeda
ml/min per kilogram
Haloperidol7.721b0.60.903
Mebendazole14.8410.220.620
Ziprasidone5.050.90.60.854

  • ↵a Fg,observed values were calculated using Eqs. 7–11.

  • ↵b The Fa value of haloperidol was assumed to be 1.