Compound | Tmax | Cmax | AUC0–t | tlast | Percentage of Parent | Percentage of Total Radioactivity |
---|---|---|---|---|---|---|
h | ng-Eq/ml | ng-Eq·h/ml | h | |||
Almorexant | 0.9 | 66.6 | 61.2 | 1.6 | 100 | 0.11 |
M3/M8 | 0.9 | 69.8 | 123 | 3.5 | 201 | 0.23 |
M5/M27 | 0.9 | 44.1 | 44.8 | 1.6 | 73.2 | 0.08 |
M6 | 1.6 | 49.0 | 331 | 11 | 541 | 0.61 |
M7/M14A/M31/M32 | 3.5 | 38.4 | 1720 | 60 | 2811 | 3.2 |
M10/M12 | 0.9 | 65.0 | 62.8 | 1.6 | 103 | 0.12 |
M11/M41 | 11 | 260 | 8460 | 60 | 13,824 | 15.6 |
M14b | 1.6 | 21.5 | 17.2 | 1.6 | 28.1 | 0.03 |
M28/M29 | 0.9 | 42.5 | 18.6 | 0.9 | 30.4 | 0.03 |
M30 | 3.5 | 45.0 | 731 | 20 | 1194 | 1.4 |
M34/M35 | 1.6 | 55.0 | 61.0 | 1.6 | 100 | 0.11 |
M37 | 1.6 | 21.5 | 17.2 | 1.6 | 28.1 | 0.03 |
M39 | 1.6 | 26.0 | 20.8 | 1.6 | 34.0 | 0.04 |
Total radioactivity | 1.6 | 1050 | 54,100 | 300 |