Percentage of GSK2251052 and M3 following 3-hour incubations of [14C]GSK2251052 (500 μM) with NAD+ (7.5 mM) at pH 7.4, 8.4, and 8.8 in monkey liver S9, cytosol, and microsomes
| Peak | Percentage of Total Radioactivity (Peak Area) | |||||
|---|---|---|---|---|---|---|
| S9 | Cytosol | Microsomes | ||||
| pH 7.4 | pH 8.4 | pH 8.8 | pH 7.4 | pH 8.4 | pH 7.4 | |
| M3 | 7.7 | 6.7 | 4.3 | 1.7 | 0.9 | 2.5 |
| GSK2251052 | 87.8 | 85.6 | 89.0 | 88.7 | 97.7 | 87.9 |
| Total | 95.5 | 92.3 | 93.3 | 90.4 | 98.6 | 90.4 |