HSP90 Inhibitor | Dose | Predicted AUC0–∞ | Predicted Vss | Predicted t1/2 | |||
---|---|---|---|---|---|---|---|
mg/kg | nM × h | (Ratio)a | l/kg | (Ratio)a | h | (Ratio)a | |
A1 | 0.75 | 613 | (1.4) | 3.6 | (1.2) | 1.2 | (0.92) |
2.5 | 1777 | (1.2) | 3.6 | (1.7) | 1.1 | (0.84) | |
7.5 | 6502 | (1.3) | 3.6 | (1.7) | 1.2 | (0.90) | |
B1 | 2.5 | 1718 | (1.2) | 3.1 | (1.7) | 0.91 | (0.72) |
C1 | 2.5 | 1794 | (1.2) | 3.7 | (2.0) | 1.1 | (0.90) |
A2 | 0.75 | 623 | (1.4) | 1.7 | (0.15) | 1.2 | (0.28) |
2.5 | 1784 | (1.2) | 1.7 | (0.13) | 1.3 | (0.16) | |
7.5 | 7150 | (1.3) | 1.7 | (0.32) | 1.1 | (0.18) | |
B2 | 2.5 | 1735 | (1.2) | 1.9 | (0.19) | 0.85 | (0.11) |
C2 | 2.5 | 1759 | (1.2) | 3.0 | (0.27) | 0.89 | (0.11) |
↵a The ratios of model-simulated to observed parameters are expressed in parentheses.