R-Lorazepam | S-Lorazepam | |||||||
---|---|---|---|---|---|---|---|---|
Liver | Km | Vmax | Ksi | CLinta | Km | Vmax | Ksi | CLinta |
µM | pmol/min/mg protein | µM | µl/min/mg | µM | pmol/min/mg protein | µM | µl/min/mg | |
H7 | 32 | 5.9 | 408 | 0.18 | 39 | 5.0 | 447 | 0.13 |
H10 | 17 | 5.0 | 424 | 0.29 | 24 | 9.3 | 381 | 0.39 |
H12 | 38 | 9.9 | 395 | 0.26 | 43 | 13 | 303 | 0.30 |
H13 | 40 | 7.1 | 252 | 0.18 | 51 | 8.7 | 229 | 0.17 |
H40 | 22 | 9.1 | 358 | 0.41 | 25 | 16 | 395 | 0.64 |
Mean ± S.D. | 29 ± 8.9 | 7.4 ± 1.9 | 367 ± 62 | 0.26 ± 0.08 | 36 ± 10* | 10 ± 3.8 | 351 ± 76 | 0.33 ± 0.18 |
Pooled HLM | 37 | 7.6 | 263 | 0.21 | 37 | 10 | 354 | 0.27 |