Risk score p for [I1]/IC50 and [I2]/IC50
PK change represents either AUC or Cmax ratio of digoxin in the absence and presence of inhibitor, value is the higher of the two PK parameters.
| Compound | PK Change | Lower Bound [I1]/IC50 | Upper Bound [I1]/IC50 | p | Lower Bound [I2]/IC50 | Upper Bound [I2]/IC50 | p |
|---|---|---|---|---|---|---|---|
| Conivaptan | 1.80 | 0.006 | 0.43 | 0.69 | 1.4 | 99 | 0.11 |
| Flecainide | 1.36 | 0.003 | 0.19 | 0.40 | 4.8 | 334 | 0.46 |
| Sparfloxacin | 1.18 | 0.001 | 0.07 | 0.12 | 1.6 | 113 | 0.13 |
| Montelukast | 1.11 | 0.013 | 0.92 | 0.89 | 1.0 | 71 | 0.06 |
| Maraviroc | 1.0 | 0.001 | 0.08 | 0.14 | 1.5 | 106 | 0.12 |
| Citalopram | 1.08 | 0.0005 | 0.03 | 0.03 | 1.0 | 71 | 0.06 |
| Aliskiren | 1.15 | 0.001 | 0.08 | 0.14 | 4.4 | 301 | 0.42 |