TABLE 3
Derived kinetic constants for S-lorazepam glucuronidation by recombinant human UDP-glucuronosyltransferase enzymes
Data are presented as the mean ± standard error of parameter fit. Data are modeled using the Hill equation.
| UGT | S50 | n | Vmax | CLmaxa |
|---|---|---|---|---|
| µM | pmol/min ⋅ mg | µl/min ⋅ mg | ||
| 2B4 | 46 ± 8 | 1.6 ± 0.2 | 0.13 ± 0.01 | 0.0015 |
| 2B7 | 17 ± 0.7 | 1.5 ± 0.06 | 0.20 ± 0.01 | 0.0062 |
| 2B15 | 23 ± 0.8 | 1.4 ± 0.04 | 0.83 ± 0.01 | 0.0198 |
↵a CLmax calculated as
.
