Rat | Mdr1a Knockout | Bcrp Knockout | Mrp2 Knockout |
---|---|---|---|
Intestine | Direction, fold change from wild type | ||
Duodenum | |||
Ces2c | ↑3.8 | — | — |
Comt | — | ↑5.2 | — |
Jejunum | |||
Comt | — | ↑2.8 | — |
Ces2c | ↑3.3 | — | — |
Cyp2d2 | ↓2.3 | ↓2.5 | — |
Ugt2b15 | ↓3.8 | ↓8.0 | — |
Ugt2b17 | ↓4.5 | ↓9.6 | ↓2.5 |
Ileum | |||
Ces2c | ↑3.8 | — | — |
Comt | — | ↑2.8 | — |
Cyp4f1 | — | ↓2.5 | — |
Liver | Direction, fold change from wild type | ||
Comt | — | ↑3.1 | — |
Cyp2b2 | ↓2.1 | ↓2.7 | ↓3.1 |
Cyp2c12 | ↑3.0 | ↑4.2 | — |
Cyp4v3 | — | ↓2.3 | — |
Fmo1 | — | — | ↓2.5 |
Ugt2b1 | ↓3.2 | — | — |
Kidney | Direction, fold change from wild type | ||
Cortex | |||
Comt | — | ↑6.1 | — |
Cyp2c11 | — | — | ↓13.6 |
Medulla | |||
Comt | — | ↑4.2 | — |
Cyp1a1 | ↓13.2 | ↓5.8 | ↓9.8 |
Cyp2c11 | ↓9.0 | — | ↓12.2 |
Cyp2c23 | ↓2.4 | — | — |
Cyp2d2 | ↓2.4 | — | ↓2.4 |
Cyp2e1 | — | ↓2.5 | ↓2.1 |
Cyp4a1 | ↓3.5 | — | ↓5.1 |
Cyp4a8 | ↓2.8 | — | — |
Cyp4f1 | ↓2.1 | — | ↓2.1 |
Cyp21a1 | ↓2.3 | — | ↓2.4 |
Cyp26b1 | ↑3.3 | — | — |
Fmo1 | ↓2.1 | — | ↓2.3 |
Oatp1a1 | ↓2.3 | — | ↓2.1 |
Brain | Direction, fold change from wild type | ||
Comt | — | ↑2.4 | — |
Cyp4v3 | — | ↓2.1 | — |
—, no change; ↑, increased; ↓, decreased; Ces, carboxylesterase; Comt, catechol-o-methyltransferase; Fmo, flavin monooxidase; Oatp, organic anion transporting polypeptide; Ugt, UDP-glucoronosyltransferase.