Digoxin transport in cell models in presence and absence of inhibitor
| Lab | Papp | ER = (B>A/A>B) | ||||
|---|---|---|---|---|---|---|
| A>B w/o Positive Control Inhibitor | A>B with Positive Control Inhibitor | B>A w/o Positive Control Inhibitor | B>A with Positive Control Inhibitor | ER w/o Inh | ER with Inh | |
| nm/s | nm/s | nm/s | nm/s | nm/s | ||
| M01 | 4.6 | 29.6 | 211.7 | 35.3 | 46.1 | 1.2 |
| M02 | 3.2 | 26.1 | 195.4 | 34.3 | 60.5 | 1.3 |
| M03 | 5.9 | 28.1 | 106.7 | 24.4 | 18.1 | 0.9 |
| M06 | 4.6 | 12.7 | 101.7 | 15.0 | 21.9 | 1.2 |
| M07 | 7.0 | 25.4 | 151.3 | 31.5 | 21.7 | 1.2 |
| M04 | 9.6 | 23.0 | 81.9 | 42.8 | 8.5 | 1.9 |
| M05 | 0.9 | 4.2 | 50.7 | 15.8 | 59.2 | 3.8 |
| Average | 5 ± 4a | 21 ± 11a | 128 ± 63a | 28 ± 12a | 25 ± 18b | 1.3 ± 1b |
| L08 | 6.3 | 26.5 | 102.6 | 46.3 | 16.4 | 1.7 |
| L09 | 6.2 | 34.3 | 86.4 | 35.4 | 14.0 | 1.0 |
| L10 | 5.9 | 35.1 | 90.3 | 48.2 | 15.4 | 1.4 |
| L11 | 9.7 | 26.7 | 58.9 | 57.2 | 6.1 | 2.1 |
| Average | 7 ± 4a | 31 ± 6a | 85 ± 21a | 47 ± 13a | 12 ± 7b | 1.5 ± 0.5b |
| C08 | 10.7 | 34.2 | 104.9 | 54.2 | 9.8 | 1.6 |
| C15 | 8.8 | 32.1 | 154.8 | 43.8 | 17.6 | 1.4 |
| C17 | 12.8 | 37.9 | 106.8 | 45.9 | 8.3 | 1.2 |
| C18 | 11 | 44.1 | 106.1 | 45.2 | 9.7 | 1.0 |
| C24 | 2.0 | 11.4 | 65.9 | 15.2 | 32.6 | 1.3 |
| C25 | 10.6 | 24.4 | 116.3 | 26.6 | 11.0 | 1.1 |
| C12 | 5.8 | 33.3 | 90.0 | 36.9 | 15.7 | 1.1 |
| C13 | 10.2 | 35.5 | 102.8 | 47.1 | 10.0 | 1.3 |
| C14 | 1.5 | 37.0 | 153.0 | 50.0 | 102.0 | 1.4 |
| C16 | 36.0 | 113.4 | 310.2 | 125.0 | 8.6 | 1.1 |
| C19 | 16.0 | 40.9 | 121.3 | 44.3 | 7.6 | 1.1 |
| Average | 11 ± 10a | 37 ± 29a | 120 ± 74a | 45 ± 31a | 11 ± 11b | 1.2 ± 1b |
↵a SD for a single reported result (average of three replicates) at a single laboratory using variance components model.
↵b Estimated SD for a single reported result (ratio of the average of three replicates) at a single laboratory (Casella and Berger, 2001). http://www.math.umt.edu/patterson/549/Delta.pdf.