TABLE 1

Compound concentrations optimized for each compound and the mass/charge (m/z) values to detect the glucuronide in LC-MS/MS analyses

CompoundsIncubation ConditionsTransitions
Compound ConcentrationQ1–Q3 (m/z)
µM
Tricyclic amines
 Amitriptyline100454–278
 Imipramine100457–281
 Ketotifen100485–309
 Pizotifen100473–296
 Olanzapine500489–313
 Trifluoperazine50585–409
 Desipramine100443 –266
 Nortriptyline100440–264
 Carbamazepine100413–237
Other amines
 Afloqualone1000461–284
 Diphenhydramine100432–256
 Tamoxifen100548–372
 Ketoconazole10709–532
 Midazolam10502–326