Species | Hydrolase Activity in Controls | Hydrolase Activity in the Presence of Esterase Inhibitors | |||
---|---|---|---|---|---|
1 mM EDTA | 0.5 mM BNPP | 0.5 mM Ethopropazine | 0.5 mM Ethopropazine and 0.5 mM BNPP | ||
nmol/min per milliliter plasma | |||||
HSA (4%) | 4.82 ± 0.15 | 3.96 ± 0.46 (82.1 ± 9.47) | 4.04 ± 0.40 (83.9 ± 9.78) | 5.51 ± 0.58 (113 ± 14.8) | |
Human | 21.6 ± 0.81 | 10.7 ± 0.63 (49.5 ± 5.50)*** | 15.1 ± 2.43 (70.3 ± 19.8)* | ||
Monkey | 19.5 ± 2.14 | 12.3 ± 1.60 (63.2 ± 5.54)* | 15.3 ± 5.04 (76.6 ± 37.6) | ||
Dog | 7.51 ± 1.09 | 5.13 ± 1.46 (68.3 ± 8.67)* | 7.06 ± 1.59 (93.7 ± 12.6) | ||
Minipig | 4.79 ± 1.66 | 4.83 ± 0.20 (101 ± 3.12) | 3.74 ± 1.67 (78.2 ± 9.21) | ||
Rabbit | 37.0 ± 2.58 | 25.4 ± 4.60 (68.6 ± 11.6)* | 3.78 ± 0.26 (10.2 ± 0.24)** | 32.7 ± 13.5 (88.3 ± 7.31) | |
Mouse | 12.3 ± 4.68 | 12.0 ± 0.37 (98.6 ± 15.6) | 1.18 ± 0.35 (10.0 ± 3.50)* | 20.5 ± 1.74 (173 ± 54.6)* | 0.76 ± 0.61 (6.75 ± 5.47)* |
Rat | 15.5 ± 2.81 | 16.0 ± 2.03 (103 ± 4.68) | 2.27 ± 0.97 (14.7 ± 4.72)* | 71.8 ± 14.3 (468 ± 70.9)** | 3.65 ± 0.45 (26.4 ± 5.77)* |
↵* P < 0.05; **P < 0.01; ***P < 0.001.