Michaelis-Menten kinetic parameters for the formation of 1-hydroxymidazolam, 4-hydroxydiclofenac, and dextrorphan from midazolam, diclofenac, and dextromethorphan in human liver microsomes
| Vmax,f | Km,f | |
|---|---|---|
| pmol/(min⋅mg) | µM | |
| 1-Hydroxymidazolam | 656 ± 23 | 2.83 ± 0.19 |
| 4′Hydroxydiclofenac | 2600 ± 40 | 7.42 ± 0.30 |
| Dextrorphan | 129 ± 4 | 6.34 ± 0.46 |