TABLE 3

Application of in vitro criteria to a test set of in vitro IC₅₀ values paired with clinical DDI data

Digoxin DDI data set contains 101 pairs of in vitro IC₅₀ data and clinical DDI data.

	[I₁]/IC₅₀	[I₂]/IC₅₀	True Positive^a	True Negative^b	False Positive^b	False Negative^a	Accuracy
FDA	0.1	10	45 (90)	25 (49)	26 (51)	5 (10)	70 (69)
ROC	0.03	45	44 (88)	30 (58)	21 (40)	6 (12)	74 (73)

Value represents total hits out of ^a50 and ^b51 pairs of in vitro IC₅₀ data and clinical DDI data.
The value in parentheses represents the percentage of cases falling under the various classifications (TP, TN, FP and FN).