In vitro cleavage rates correlated with observed in vivo changes in exposure
| Drug | Normalized Rate of Metabolism | Fold-Increase in Cmax | Fold-Increase in AUC |
|---|---|---|---|
| ml/IU per minute | |||
| Fosphenytoin to phenytoin | 33.00 | 3.7 | 2.1 |
| Clindamycin phosphate to clindamycin | 2.01 | 1.0 | 2.3 |
| Ritonavir phosphate to ritonavir | <0.19 | No exposure | |
| Ritonavir oxymethyl phosphate to ritonavir | 1.76 | 1.9 | 2.5 |
| Dexamethasone phosphate to dexamethasone | 13.59 | 13.5 | 2.1 |