Nominal Cinh | Observed Cinh | |||||
---|---|---|---|---|---|---|
Compound | P450 | IC50 | Shifted IC50 | Fold Shift | Shifted IC50 | Fold Shift |
Clarithromycin | CYP3A4 | 130 | 41.4 | 3.1 | 41.4 | 3.1 |
Dasatinib | CYP3A4 | 9.6 | 2.6 | 3.7 | 2.2 | 4.4 |
Delavirdine | CYP3A4 | 19.3 | 0.79 | 24.4 | 0.53 | 36.4 |
CYP2C9 | 5.6 | 6.0 | 0.9 | 5.8 | 1.0 | |
CYP2D6 | 51.4 | 10.7 | 4.8 | 13.1 | 3.9 | |
Diltiazem | CYP3A4 | 72.8 | 36.2 | 2.0 | 36.2 | 2.0 |
Erythromycin | CYP3A4 | 43.7 | 18.0 | 2.4 | 18.0 | 2.4 |
Ketoconazole | CYP3A4 | 0.013 | 0.021 | 0.6 | 0.0099 | 1.3 |
CYP2C9 | 9.8 | 8.4 | 1.2 | 8.4 | 1.2 | |
Mibefradil | CYP3A4 | 0.42 | 0.029 | 14.5 | 0.0076 | 55.3 |
CYP2D6 | 1.2 | 0.51 | 2.4 | 0.46 | 2.6 | |
Mifepristone | CYP3A4 | 5.0 | 0.43 | 11.6 | 0.12 | 41.7 |
CYP2C9 | 4.9 | 2.7 | 1.8 | 1.3 | 3.8 | |
CYP2D6 | 7.1 | 16.3 | 0.4 | 12.5 | 0.6 | |
Nefazodone | CYP3A4 | 2.1 | 0.23 | 9.1 | 0.0033 | 636 |
CYP2C9 | 23.3 | 32.8 | 0.7 | 28.0 | 0.8 | |
Nicardipine | CYP3A4 | 0.49 | 0.11 | 4.5 | 0.00028 | 1750 |
CYP2C9 | 0.35 | 1.7 | 0.2 | 0.30 | 1.2 | |
CYP2D6 | 1.5 | 6.2 | 0.2 | 2.8 | 0.5 | |
Paroxetine | CYP2D6 | 0.9 | 0.037 | 24.6 | 0.024 | 37.9 |
Ritonavir | CYP3A4 | 0.0082 | 0.0090 | 0.9 | 0.00018 | 45.6 |
CYP2C9 | 2.0 | 2.2 | 0.9 | 2.2 | 0.9 | |
CYP2D6 | 1.0 | 2.9 | 0.3 | 2.9 | 0.3 | |
Saquinavir | CYP3A4 | 0.50 | 1.0 | 0.5 | 0.033 | 15.2 |
CYP2C9 | 29.2 | 33.9 | 0.9 | 31.2 | 0.9 | |
CYP2D6 | 8.4 | 8.5 | 1.0 | 3.5 | 2.4 | |
Tienilic acid | CYP2C9 | 0.90 | 0.072 | 12.5 | 0.018 | 50.0 |
Troleandomycin | CYP3A4 | 4.7 | 1.1 | 4.3 | 0.19 | 24.7 |
Verapamil | CYP3A4 | 21.7 | 7.2 | 3.0 | 6.5 | 3.3 |