The systemic AUCs, portal AUCs, and Fa·Fg of FEX (5 mg/kg), SASP (5 mg/kg), and TPT (0.3 mg/kg) after pretreatment with ZSQ (30 mg/kg) and/or Ko143 (10 mg/kg) in the portal vein–cannulated rats
| Substrate | Pretreatment | AUCsys | AUCpor | Rb | Fa·Fg |
|---|---|---|---|---|---|
| ng·h/ml | ng·h/ml | ||||
| FEX | Control | 59.9 ± 40.9 | 617 ± 490 | 0.99 | 0.22 ± 0.18 |
| ZSQ | 431 ± 63*** | 2563 ± 286*** | 0.84 ± 0.10*** | ||
| Ko143 | 55.0 ± 19.7‡‡‡ | 565 ± 118‡‡‡ | 0.20 ± 0.05‡‡‡ | ||
| ZSQ + Ko143 | 284 ± 39***##††† | 2243 ± 330***††† | 0.77 ± 0.13***††† | ||
| SASP | Control | 366 ± 37 | 499 ± 42 | 0.58 | 0.03 ± 0.01 |
| ZSQ | 339 ± 29 | 443 ± 32 | 0.02 ± 0.01 | ||
| Ko143 | 2881 ± 646***‡‡‡ | 3492 ± 716***‡‡‡ | 0.14 ± 0.07*‡ | ||
| ZSQ + Ko143 | 2529 ± 549***### | 3146 ± 411***### | 0.14 ± 0.04*# | ||
| TPT | Control | 18.3 ± 1.6 | 30.9 ± 1.5 | 1.26 | 0.11 ± 0.03 |
| ZSQ | 36.2 ± 13.7 | 63.8 ± 19.4 | 0.23 ± 0.07 | ||
| Ko143 | 69.0 ± 17.5**‡ | 119 ± 18***‡‡ | 0.42 ± 0.10* | ||
| ZSQ + Ko143 | 122 ± 15***###††† | 200 ± 35***###††† | 0.64 ± 0.20***### |
Values represent the mean ± S.D. for three to five rats. Statistically significant differences: *P < 0.05, **P < 0.01, ***P < 0.001, control versus ZSQ, Ko143, or ZSQ+Ko143; ‡P < 0.05, ‡‡P < 0.01, ‡‡‡P < 0.001, ZSQ versus Ko143; #P < 0.05; ##P < 0.01; ###P < 0.001, ZSQ versus ZSQ+Ko143; †††P < 0.001, Ko143 versus ZSQ+Ko143.