TABLE 1

Rifampicin measurements during the rinse period

Two time points are available: 90 and 105 minutes.

Experimental Groups	Time	Hepatic Concentrations	Bile Efflux Rates	Perfusate Efflux Rates
	min	nmol/g	nmol/min
100 μM RIF in normal livers	90	380 ± 110	3.3 ± 1.3	216 ± 39
	105	197 ± 64	2.3 ± 0.8	71 ± 31
100 μM RIF in liver lacking Mrp2	90	538 ± 215^{^a}	0^{^a}	269 ± 32
	105	270 ± 100^{^a}	0^{^a}	85 ± 7
100 μM RIF and 200 μM BOPTA	90	348 ± 194	3.1 ± 0.7	244 ± 61
	105	151 ± 44	2.3 ± 0.7	53 ± 34
10 μM RIF and 200 μM BOPTA	90	103 ± 40	0.9 ± 0.2	58 ± 9
	105	71 ± 19	0.5 ± 0.1	26 ± 9
1 μM RIF and 200 μM BOPTA	90	46 ± 24	0.2 ± 0.1	15 ± 11
	105	22 ± 23	0.1 ± 0 1	7 ± 6