TABLE 1

Pharmacokinetic parameters of FEX (1 mg/kg) after oral (30 mg/kg) and intravenous (2 mg/kg) administration of ZSQ

	AUC	t_1/2	CL_tot	Vd_ss
	ng·h/ml	h	ml/min/kg	ml/kg
Control	428 ± 41	2.1 ± 0.2	39.3 ± 4.0	1.9 ± 0.3
ZSQ p.o.	587 ± 58**	1.4 ± 0.1***	28.6 ± 3.0**	1.4 ± 0.2*
ZSQ i.v.	570 ± 34**	1.4 ± 0.1***	29.3 ± 1.9**	1.1 ± 0.2**

ZSQ p.o., ZSQ was orally administered 40 minutes before FEX was intravenously administered. ZSQ i.v., ZSQ, and FEX were intravenously coadministered. Values represent the mean ± S.D. for three to four rats.
Vd_ss, volume of distribution at steady state. Statistically significant differences: *P < 0.05; **P < 0.01; ***P < 0.001, control versus ZSQ p.o. or ZSQ i.v.