AUC | t1/2 | CLtot | Vdss | |
---|---|---|---|---|
ng·h/ml | h | ml/min/kg | ml/kg | |
Control | 428 ± 41 | 2.1 ± 0.2 | 39.3 ± 4.0 | 1.9 ± 0.3 |
ZSQ p.o. | 587 ± 58** | 1.4 ± 0.1*** | 28.6 ± 3.0** | 1.4 ± 0.2* |
ZSQ i.v. | 570 ± 34** | 1.4 ± 0.1*** | 29.3 ± 1.9** | 1.1 ± 0.2** |
ZSQ p.o., ZSQ was orally administered 40 minutes before FEX was intravenously administered. ZSQ i.v., ZSQ, and FEX were intravenously coadministered. Values represent the mean ± S.D. for three to four rats.
Vdss, volume of distribution at steady state. Statistically significant differences: *P < 0.05; **P < 0.01; ***P < 0.001, control versus ZSQ p.o. or ZSQ i.v.