TABLE 2

Dose-corrected slopes of the partial cumulative AUC of acyclovir versus time after escalating oral doses of [³H]valacyclovir in wild-type (WT) and PepT1 knockout (KO) mice

Dose (nmol/g)	Slope (5–60 min)			Slope (90–180 min)
Dose (nmol/g)	WT	KO	Ratio (KO/WT)	WT	KO	Ratio (KO/WT)
10	0.27	0.06	0.22	0.09	0.08	0.83
25	0.28	0.04	0.15	0.08	0.06	0.79
50	0.31	0.06	0.20	0.12	0.10	0.83
100	0.27	0.05	0.17	0.11	0.08	0.76