Inactivation kinetics of selected milk thistle constituents and extract
Values represent the estimate ± S.E. from nonlinear regression using WinNonlin (version 5.3).
| Constituent/Extract | KI | kinact | kinact/KI | t1/2 | kzero |
|---|---|---|---|---|---|
| μM | min−1 | μl/min/pmol | min | min−1 | |
| Silybin A | 100 ± 27 | 0.22 ± 0.02 | 2.2 | 3.2 | 0.025 ± 0.005 |
| Silybin B | 89 ± 60 | 0.15 ± 0.04 | 1.7 | 4.5 | 0.023 ± 0.008 |
| Silibinin | 110 ± 15 | 0.20 ± 0.01 | 1.8 | 3.5 | 0.016 ± 0.002 |
t1/2, half-life.