Intrinsic clearance of the three AOX1 substrates in 21 human liver cytosols
| Lot ID | CLint, in vitro | ||
|---|---|---|---|
| Carbazeran | Zoniporide | Phthalazine | |
| µl/min per milligram | |||
| F01 | 485 ± 25 | 32.6 ± 0.6 | 592 ± 64 |
| F02 | 132 ± 7 | 9.6 ± 0.7 | 363 ± 59 |
| F03 | 544 ± 40 | 49.0 ± 1.5 | 624 ± 25 |
| F04 | 23 ± 2 | 3.6 ± 0.4 | 36 ± 9 |
| F05 | 464 ± 33 | 34.4 ± 3.0 | 525 ± 39 |
| F06 | 500 ± 52 | 42.2 ± 2.8 | 586 ± 90 |
| F07 | 457 ± 40 | 31.9 ± 2.3 | 609 ± 67 |
| F08 | 448 ± 120 | 34.2 ± 2.6 | 631 ± 77 |
| F09 | 467 ± 102 | 44.2 ± 1.4 | 587 ± 77 |
| F10 | 423 ± 58 | 30.2 ± 0.9 | 500 ± 54 |
| M01 | 32 ± 22 | 11.0 ± 15.6 | 36 ± 4 |
| M02 | 730 ± 144 | 153.6 ± 4.2 | 352 ± 115 |
| M03 | 51 ± 1 | 5.7 ± 0.3 | 126 ± 8 |
| M04 | 973 ± 21 | 73.1 ± 1.8 | 336 ± 14 |
| M05 | 2075 ± 125 | 147.5 ± 4.0 | 620 ± 51 |
| M06 | 453 ± 85 | 35.0 ± 6.1 | 604 ± 62 |
| M07 | 304 ± 4 | 21.3 ± 3.1 | 623 ± 8 |
| M08 | 502 ± 58 | 50.2 ± 4.1 | 537 ± 26 |
| M09 | 435 ± 67 | 35.1 ± 1.0 | 603 ± 29 |
| M10 | 379 ± 6 | 20.5 ± 0.6 | 578 ± 51 |
| Pooled lot | 451 ± 39 | 30.0 ± 1.7 | 612 ± 91 |