TABLE 1

Comparison of IC50s for milk thistle constituents under reversible inhibition experimental design

Values represent the estimate ± S.E. from nonlinear regression using WinNonlin (version 5.3).

Enzyme SourceIC50 of:
Silybin ASilybin BIsosilybin AIsosilybin BSilychristin
μM
HLMs180 ± 16150 ± 7.6N.D.56 ± 4.490 ± 8.8
HIMs130 ± 1290 ± 10N.D.60 ± 4.893 ± 8.7
  • N.D., not determined due to insolubility at concentrations of >100 μM.