TABLE 1

Km and kcat values for the CYP2B6-catalyzed deethylation of EFC in the presence of RTV

The EFC concentrations used were 1, 2.5, 5, 10, 25, and 50 μM.

RTVKmkcat
μMμMmin−1
01.830.80
0.12.050.67
0.32.470.54
0.62.680.44
1.04.000.37