Constituent/Extract | Enzyme Source | ||||||||
---|---|---|---|---|---|---|---|---|---|
HLMs | HIMs | rCYP3A4 | |||||||
IC50 | Fold Change | IC50 | Fold Change | IC50 | Fold Change | ||||
− NADPHa | + NADPHb | − NADPH | + NADPH | − NADPH | + NADPH | ||||
μM | μM | μM | |||||||
Silybin A | 120 ± 4.8 | 28 ± 3.1 | 4.3 | 100 ± 6.9 | 23 ± 1.7 | 4.3 | 53 ± 2.0 | 1.6 ± 0.2 | 33 |
Silybin B | 140 ± 5.7 | 19 ± 2.1 | 7.4 | 100 ± 3.8 | 27 ± 1.9 | 3.7 | 63 ± 3.2 | 1.4 ± 0.2 | 45 |
Silibinin | 120 ± 5.7 | 14 ± 2.2 | 8.6 | 67 ± 7.9 | 15 ± 3.0 | 4.5 | 45 ± 2.8 | 1.2 ± 0.2 | 38 |
Silychristin | 26 ± 3.3 | 52 ± 5.2 | 0.5 | 25 ± 4.2 | 72 ± 7.7 | 0.3 | N.D. | N.D. | N.D. |
Isosilybin B | 78 ± 6.2 | 30 ± 3.3 | 2.6 | 54 ± 3.3 | 23 ± 2.3 | 2.3 | N.D. | N.D. | N.D. |
Silymarin | 95 ± 12 | 28 ± 4.5 | 3.4 | 29 ± 2.7 | 7.0 ± 0.8 | 4.1 | N.D. | N.D. | N.D. |