TABLE 1

Some P450 drug-metabolizing enzymes and ABC transporters shown to be targeted by noncoding miRNAs

MicroRNAReference
EnzymesCYP1B1miR-27bTsuchiya et al., 2006
CYP2E1miR-378Mohri et al., 2010
CYP3A4miR-27b, mmu-miR-298Pan et al., 2009a
TransportersABCB1miR-451Kovalchuk et al., 2008
miR-27aZhu et al., 2008
ABCG2miR-520hLiao et al., 2008; Wang et al., 2010; Li et al., 2011
miR-519cTo et al., 2008; To et al., 2009; Li et al., 2011
miR-328Pan et al., 2009b; Li et al., 2011
ABCC1miR-134Guo et al., 2010
miR-326Liang et al., 2010
miR-199a, miR-199b, miR-296Borel et al., 2012
miR-1291Pan et al., 2013
ABCC2miR-379Haenisch et al., 2011
ABCC3miR-9-3pJeon et al., 2011
ABCC4miR-125a, miR-125bBorel et al., 2012
ABCC5miR-101, miR-125a, Let-7aBorel et al., 2012
miR-128Zhu et al., 2011
ABCC6miR-9-3pJeon et al., 2011