Effect of rifampin on the expression of clinically important P450 mRNAs in hepatocytes
| Gene | Fold Changea | P Value | FDR | Examples of Substrate Drugs |
|---|---|---|---|---|
| CYP3A4 | 22.1 | 0 | 0 | Erythromycin, midazolam |
| CYP2A6 | 5.5 | 1.52 × 10−141 | 2.22 × 10−138 | Letrozole, nicotine |
| CYP3A5 | 5.0 | 1.07 × 10−139 | 1.41 × 10−136 | Tacrolimus, vincristine |
| CYP2C8 | 3.8 | 1.48 × 10−96 | 1.39 × 10−93 | Paclitaxel, repaglinide |
| CYP2B6 | 3.6 | 2.01 × 10−269 | 1.28 × 10−265 | Efavirenz, bupropion |
| CYP2C9 | 2.0 | 2.89 × 10−28 | 7.03 × 10−26 | S-Warfarin, tolbutamide |
| CYP4F2 | 1.3 | 0.0001 | 0.002 | S-Warfarin |
| CYP2D6 | 1.3 | 0.0007 | 0.008 | Codeine, venlafaxine |
| CYP1A2 | 1.2 | 0.0182 | 0.094 | Caffeine, fluvoxamine |
| CYP2C19 | 1.1 | 0.0315 | 0.136 | Clopidogrel, omeprazole |
FDR, false discovery rate.
↵a Rifampin/control.