TABLE 2

The steady-state pharmacokinetic parameters of silybin A, silybin B, and isosilybin B in healthy volunteers orally administered with one capsule of silymarin extract (Legalon, 175 mg) three times daily for 28 days

The Tmax values are expressed as median (range) and other parameters are the mean ± S.D. (n = 13).

Silybin ASilybin BIsosilybin B
Tmax (h)2.0 (0.5–3.0)1.0 (0.5–3.0)2.0 (0.5–3.0)
Ctrough (ng/ml)5.9 ± 7.92.2 ± 2.50.9 ± 1.2
Cmax (ng/ml)134.7 ± 72.042.1 ± 27.326.8 ± 19.9
AUC0–8h(ng×h/ml)375.6 ± 200.899.7 ± 61.866.8 ± 48.4