Important Enzymes of P450 Superfamily | IC50 | Ki |
---|---|---|
nM | ||
Recombinant CYP19 | 131 ± 54 | 70 ± 9 |
Recombinant CYP1A2 | 207 ± 26 | 76 ± 3 |
Recombinant CYP2A6 | 6373 ± 983 | 2176 ± 256 |
Recombinant CYP3A4 | 285 ± 81 | 375 ± 6 |
Recombinant CYP3A5 | 723 ± 27 | 829 ± 62 |
Recombinant CYP2C19 | 2.80 ± 0.29 | 0.56 ± 0.02 |
Recombinant CYP2B6 | No inhibitiona | |
Recombinant CYP2D6 | No inhibitiona |
↵a No inhibition of CYP2B6 or CYP2D6 by norendoxifen was observed at the concentration of 5 μM.