TABLE 3

Subsystem prediction of altered metabolic pathways in Oat3 knockout

Transcriptomic analysis was carried out using Affymetrix mouse gene expression array. The most significantly altered sybsystems were listed. It appears that arginine and proline metabolism, blood group biosynthesis, fatty acid metabolism were predicted to be increased in Oat3-deficient kidney, whereas glutathione metabolism, glycine, serine, and threonine metabolism were predicted to be reduced in the Oat3-deficient kidney.