Parameter | Dose (nmol/g) | ||||
---|---|---|---|---|---|
10 | 25 | 50 | 100 | ||
WT | Tmax (min) | 24 ± 4 | 19 ± 3 | 15 ± 0 | 15 ± 0 |
Cmax (µM) | 3.8 ± 0.5 | 9.6 ± 0.5 | 20.9 ± 1.5 | 40.6 ± 6.8 | |
AUC0-180 (min × μM) | 278 ± 13 | 663 ± 34 | 1675 ± 66 | 2923 ± 190 | |
KO | Tmax (min) | 71 ± 11* | 96 ± 16** | 156 ± 24** | 150 ± 19** |
Cmax (µM) | 0.9 ± 0.1** | 1.7 ± 0.1*** | 5.0 ± 0.5*** | 8.8 ± 0.5* | |
AUC0–180 (min × μM) | 128 ± 8*** | 235 ± 11*** | 743 ± 78*** | 1233 ± 79** |
↵* P < 0.05, **P < 0.01 and ***P < 0.001 compared with WT mice.