Summary of immunohistochemical localization of drug transporters in human ocular tissues and immunofluorescence microscopy in the HCEC and ARPE-19
| Ocular Tissue | MRP1 | MRP2 | MRP3 | MRP4 | MRP5 | MRP6 | MRP7 | MDR1 | LRP | BCRP |
|---|---|---|---|---|---|---|---|---|---|---|
| Corneal Epithelium | + | + | + | + | + | + | + | + | + | — |
| Conjunctiva Epithelium | +++ | + | + | + | + | + | ++ | ++ | ++ | + |
| Iris-Ciliary Body | ++ | ++ | — | — | — | + | + | ++ | + | — |
| Retina | +++ | +++ | + | — | — | ++ | + | ++ | + | — |
| HCEC | + | + | + | — | — | + | + | ++ | + | — |
| ARPE-19 | — | — | — | — | — | — | ++ | ++ | + | + |