Partial list of enzyme transcripts (including some Ests) upregulated in Oat3-knockout kidney
Multiple probes for Phase I (i.e., CYP2b10 isoform 1) and Phase II (i.e., UGT2B5) drug metabolizing enzyme displayed similar levels of expression change. The elevated expression observed for 3-oxo-5-alpha-steroid 4-dehydrogenase 2 suggests enhanced enzymatic metabolism for steroid hormones, many of which are known OAT3 substrates.
| Affy. ID | Gene Name | Description | Fold Change |
|---|---|---|---|
| 1423397_at | Ugt2b5 | UGT2B5 | 371.9 |
| 1440339_at | Enpp1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1 | 120.2 |
| 1459311_at | Est | cAMP-specific 3′,5′-cyclic phosphodiesterase 4D-like | 14.6 |
| 1449486_at | Ces1 | Carboxylesterase 1 | 4.5 |
| 1422257_s_at | Cyp2b10 | CYP2b10 isoform 1 | 4.2 |
| 1440463_at | Est | Similar to peptide N-glycanase (Ngly1) gene | 4.0 |
| 1422960_at | Srd5a2 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 3.7 |
| 1444032_at | Keg1 | Glycine N-acyltransferase-like protein Keg1 | 3.7 |