Enhanced RECON 1 enzyme reactions in the Oat3 knockout
This is a list of significantly enhanced RECON 1 enzyme reactions (without exchange, transport or biomass-growth related reactions) in the Oat3 knockout.
| Enzyme Reactions | Reaction Name | Subsystem |
|---|---|---|
| P4508B11r | Sterol 12-alpha-hydroxylase | Bile acid biosynthesis |
| P4508B13r | Sterol 12-alpha-hydroxylase (nadh) | Bile acid biosynthesis |
| B3GNT51g | UDP-GlcNAc:bGal b-1,3-N-acetylglucosaminyltransferase 5 | Glycan biosynthesis |
| ST3GAL31g | ST3β-galactoside alpha-2,3-sialyltransferase 3 | Glycan biosynthesis |
| HMGCOASim | Hydroxymethylglutaryl CoA synthase (ir) | Cholesterol metabolism |
| GALT2g | UDP-D-galactose:galactosylxylose galactosyltransferase, Golgi | Chondroitin/heparin sulfate biosynthesis |
| S3T2g | Heparin-glucosamine 3-O-sulfotransferase | Chondroitin/heparin sulfate biosynthesis |
| LTA4H | Leukotriene A-4 hydrolase | Eicosanoid metabolism |
| PGISr | Prostaglandin I2 synthase | Eicosanoid metabolism |
| DHFRa | Dihydrofolate reductase | Folate metabolism |
| MTHFDa | Methylenetetrahydrofolate dehydrogenase (NADP) | Folate metabolism |
| HAS1 | Hyaluronan synthase | Hyaluronan metabolism |
| HAS2 | Hyaluronan synthase | Hyaluronan metabolism |
| S23T3g | β-Galactoside α-2,3-sialyltransferase (complex N-glycan) | Keratan sulfate biosynthesis |
| HSD17B3r | Testicular 17β-hydroxysteroid dehydrogenase | Steroid metabolism |
| PYDXDH | Pyridoxal dehydrogenase | Vitamin B6 metabolism |
| S23T3g | β-Galactoside α-2,3-sialyltransferase (T antigen) | O-glycan biosynthesis |
| MTHFCa | Methenyltetrahydrofolate cyclohydrolase | Folate metabolism |
| 34HPLFM | 3-(4-Hydroxyphenyl-)lactate formation | Ubiquinone biosynthesis |
↵a Enhanced reactions related to folate metabolism (DHFR, MTHFD and MTHFC) are highlighted in Fig. 2.