Percentage of metformin oral dose in liver or kidneys over a pharmacologically relevant dose range and time frame in mice
Data are presented as the mean ± S.E.M. n = 3–4 mice per time per dose.
| Dose (mg/kg) | Time Postdose | ||
|---|---|---|---|
| 1.5 h | 2.0 h | 2.5 h | |
| Percentage of Metformin Oral Dose in Liver | |||
| 10 | 1.40 ± 0.19 | 0.81 ± 0.14 | 0.63 ± 0.08 |
| 30 | 1.64 ± 0.33 | 1.12 ± 0.04 | 1.79 ± 0.95 |
| 60 | 0.97 ± 0.17 | 0.89 ± 0.16 | 0.49 ± 0.04 |
| 100 | 2.36 ± 0.30 | 0.77 ± 0.07 | 1.48 ± 0.10 |
| 300 | 0.20 ± 0.06 | 0.19 ± 0.03 | 0.14 ± 0.04 |
| Percentage of Metformin Oral Dose in Kidneys | |||
| 10 | 1.58 ± 0.19 | 1.37 ± 0.17 | 1.61 ± 0.42 |
| 30 | 0.85 ± 0.15 | 0.78 ± 0.12 | 0.77 ± 0.05 |
| 60 | 0.46 ± 0.03 | 0.61 ± 0.14 | 0.63 ± 0.13 |
| 100 | 1.20 ± 0.31 | 1.32 ± 0.39 | 0.58 ± 0.14 |
| 300 | 0.10 ± 0.02 | 0.63 ± 0.49 | 0.47 ± 0.31 |