Model parameter estimates in the 24-hour MA period and no MA period
| Parameter | 24-Hour MA Period | No MA Period | ||||
|---|---|---|---|---|---|---|
| Population Mean Estimate | RSE% | CV% | Population Mean Estimate | RSE% | CV% | |
| ka (h−1) | 3.65 | 41.6 | 103 | 3.55 | 54.9 | 56.0 |
| k12 (h−1) | 1.71 | 19.4 | 32.5 | 1.54 | 71.5 | 62.6 |
| k21 (h−1) | 2.02 | 14.4 | 23.1 | 2.40 | 64.9 | 29.7 |
| V1 (liters) | 31.2 | 38.8 | 17.7 | 27.7 | 56.8 | 20.2 |
| V2 (liters) | 24.4 | 47.2 | 24.6 | 18.4 | 52.8 | 37.2 |
| TLag (h−1) | 0.15 | 54.5 | 107 | 0.14 | 76.2 | 81.2 |
| CLCAPX (l/h) | 2.73 | 15.0 | 22.7 | 2.63 | 17.3 | 19.6 |
| CLPX (l/h) | 3.81 | 11.2 | 13.4 | 3.70 | 14.2 | 10.9 |
| CLCAO (l/h) | 4.86 | 40.1 | 57.1 | 3.74 | 49.0 | 68.1 |
| IC(1) (mg) | 1.72 | 82.3 | 229 | 3.40 | 144 | 187 |
| IC(2) (mg) | 1.20 | Fixed | — | 1.21 | Fixed | — |
| IC(3) (mg) | 4.06 | 22.8 | 48.2 | 6.93 | 77.2 | 103 |
| IC(4) (mg) | 1.37 | Fixed | — | 1.18 | Fixed | — |
| SD1intercept | 0.05 | Fixed | — | 0.05 | Fixed | — |
| SD1slope | 0.02 | 38.8 | — | 0.07 | 13.7 | — |
| SD2intercept | 0.05 | Fixed | — | 0.05 | Fixed | — |
| SD2slope | 0.04 | 32.2 | — | 0.04 | 29.9 | — |
CV%, coefficient of variation percentage (represents the true biologic variability between the participants); IC(i), Initial condition in the ith compartment; RSE%, relative standard error as a percentage (represents the precision of the parameter estimate); SD1intercept, variance model parameter describing additive residual error of caffeine; SD1slope, variance model parameter describing the proportional residual error of caffeine; SD2intercept, variance model parameter describing additive residual error of paraxanthine; SD2slope, variance model parameter describing proportional residual error of paraxanthine.